Histopathological and Some Biochemical Effects of Platinum Drug on the Liver and Kidney of Pregnant Mice Mus musculus and their Embryos | ||
| Iraqi Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof , Available Online from 01 June 2020 | ||
| Document Type: Research Paper | ||
| DOI: 10.33899/ijvs.2020.126793.1382 | ||
| Authors | ||
Baidaa A. barwarei   1; Hanan S. Sadoon2 | ||
| 1Department of Biology , Collage of Education for Pure Science , Mosul University , Mosul ,Iraq | ||
| 2Department of Biology, College of Education For Pure Science, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| The current study was done to investigate the effect of two doses 3, 6 mg/kg b.w. of Platinum drug on the structure of the liver and kidneys of pregnant mice and their embryos and weight changes including ; mothers body weight, embryos,maternal liver and kidneys, as well as some serum biochemical parameters were established. Thirty pregnant mice were used and they were divided into three groups (10 mice/group),as the following ; group I (control group); animals were injected intraperitonialy (IP) with distilled water on the days 7th,12th,and 17th of gestation,whilst groups II,III were injected intraperitonialy (IP) with the selected doses above of platinum on the days 7th, 12th, 17th of gestation,respectively. Microscopically; maternal and fetal' liver sections of group II revealed; vaculation, swelling, apoptosis and infiltration of inflammatory cells, congestion, degeneration and involvement of extra medullary hematopoietic cells, respectively. Pervious lesions were increased in both maternal and fetal’ liver of group III. Maternal and fetal kidney sections of group II revealed ; degeneration, expansion of Bowman's space, inflammatory cells infiltration into interstitial tissue, and blood capillary congestion The previous lesions showed more severity in group III. | ||
| Keywords | ||
| Platinum; Cisplatin; pregnancy; Embryos; Mice | ||
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